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Neoadjuvant chemoradiotherapy for resectable esophageal carcinoma: a meta-analysis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jin, Hai-Lin Zhu, Huisheng Ling, Ting-Sheng Zhang, Heping Shi, Rui-Hua |
| Copyright Year | 2009 |
| Abstract | AIM To compare neoadjuvant chemoradiotherapy and surgery with surgery alone for resectable esophageal carcinoma. METHODS We used MEDLINE and EMBASE databases to identify eligible studies and manual searches were done to ensure no studies were missed. Trial validity assessment was performed and a trial quality score was assigned. RESULTS Eleven randomized controlled trials (RCTs) including 1308 patients were selected. Neoadjuvant chemoradiotherapy significantly improved the overall survival compared with surgery alone. Odds ratio (OR) [95% confidence interval (CI), P value], expressed as neoadjuvant chemoradiotherapy and surgery vs surgery alone, was 1.28 (1.01-1.64, P = 0.05) for 1-year survival, 1.78 (1.20-2.66, P = 0.004) for 3-year survival, and 1.46 (1.07-1.99, P = 0.02) for 5-year survival. Postoperative mortality increased in patients treated by neoadjuvant chemoradiotherapy (OR: 1.68, 95% CI: 1.03-2.73, P = 0.04), but incidence of postoperative complications was similar in two groups (OR: 1.14, 95% CI: 0.88-1.49, P = 0.32). Neoadjuvant chemoradiotherapy lowered the local-regional cancer recurrence (OR: 0.64, 95% CI: 0.41-0.99, P = 0.04), but incidence of distant cancer recurrence was similar (OR: 0.94, 95% CI: 0.68-1.31, P = 0.73). Histological subgroup analysis indicated that esophageal squamous cell carcinoma did not benefit from neoadjuvant chemoradiotherapy, OR (95% CI, P value) was 1.16 (0.85-1.57, P = 0.34) for 1-year survival, 1.34 (0.98-1.82, P = 0.07) for 3-year survival and 1.41 (0.98-2.02, P = 0.06) for 5-year survival. CONCLUSION Neoadjuvant chemoradiotherapy can raise the survival rate of patients with esophageal adenocarcinoma. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.crd.york.ac.uk/crdweb/PrintPDF.php?AccessionNumber=12010001204&Copyright=Database+of+Abstracts+of+Reviews+of+Effects+(DARE)%3Cbr+/%3EProduced+by+the+Centre+for+Reviews+and+Dissemination+%3Cbr+/%3ECopyright+%26copy%3B+2017+University+of+York%3Cbr+/%3E |
| Alternate Webpage(s) | http://or.nsfc.gov.cn/bitstream/00001903-5/123404/1/1000002099116.pdf |
| PubMed reference number | 20014464v1 |
| Volume Number | 15 |
| Issue Number | 47 |
| Journal | World journal of gastroenterology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adenocarcinoma Chemoradiotherapy Confidence Intervals Distant Metastasis Esophageal carcinoma Keratinized squamous cell of esophagus Locally Metastatic Malignant Neoplasm Neoadjuvant Therapy Overall Survival Patients PersonNameUse - assigned Postoperative Complications Randomized Controlled Trials as Topic Squamous Epithelial Cells Squamous cell carcinoma of esophagus |
| Content Type | Text |
| Resource Type | Article |
