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Ab and T cell epitopes of influenza A virus, knowledge and opportunities.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bui, Huynh-Hoa Peters, Bjoern Assarsson, Erika Mbawuike, Innocent Nnadi Sette, Alessandro |
| Copyright Year | 2007 |
| Abstract | The Immune Epitope Database and Analysis Resources (IEDB) (www.immuneepitope.org) was recently developed to capture epitope related data. IEDB also hosts various bioinformatics tools that can be used to identify novel epitopes as well as to analyze and visualize existing epitope data. Herein, a comprehensive analysis was undertaken (i) to compile and inventory existing knowledge regarding influenza A epitopes and (ii) to determine possible cross-reactivities of identified epitopes among avian H5N1 and human influenza strains. At present, IEDB contains >600 different epitopes derived from 58 different strains and 10 influenza A proteins. By using the IEDB analysis resources, conservancy analyses were performed, and several conserved and possibly cross-reactive epitopes were identified. Significant gaps in the current knowledge were also revealed, including paucity of Ab epitopes in comparison with T cell epitopes, limited number of epitopes reported for avian influenza strains/subtypes, and limited number of epitopes reported from proteins other than hemagglutinin and nucleoprotein. This analysis provides a resource for researchers to access existing influenza epitope data. At the same time, the analysis illustrates gaps in our collective knowledge that should inspire directions for further study of immunity against the influenza A virus. |
| Starting Page | 1843 |
| Ending Page | 1848 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.pnas.org/content/104/1/246.full.pdf |
| Alternate Webpage(s) | http://www.pnas.org/content/104/1/246.full.pdf?with-ds=yes |
| PubMed reference number | 17200302v1 |
| Volume Number | 104 |
| Issue Number | 1 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aves Bio-Informatics Cross Reactions Epitopes Influenza A virus Influenza in Birds Influenza virus vaccine Nucleoproteins Subtype (attribute) |
| Content Type | Text |
| Resource Type | Article |
