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Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhao, Min Liu, Kefang Luo, Jiejian Tan, Shuguang Quan, Chuansong Zhang, Shuijun Chai, Yan Qi, Jianxun Li, Yan Bi, Yuhai Xiao, Haixia Wong, Gary Xunwei Zhou, Jianfang Jiang, Taijiao Liu, Wenjun Yu, Hongjie Yan, Jinghua Liu, Yingxia Shu, Yuelong Wu, Guizhen Wu, Aiping Gao, George Fu Liu, William J. |
| Copyright Year | 2018 |
| Abstract | Against a backdrop of seasonal influenza virus epidemics, emerging avian influenza viruses (AIVs) occasionally jump from birds to humans, posing a public health risk, especially with the recent sharp increase in H7N9 infections. Evaluations of cross-reactive T-cell immunity to seasonal influenza viruses and human-infecting AIVs have been reported previously. However, the roles of influenza A virus-derived epitopes in the cross-reactive T-cell responses and heterosubtypic protections are not well understood; understanding those roles is important for preventing and controlling new emerging AIVs. Here, among the members of a healthy population presumed to have previously been infected by pandemic H1N1 (pH1N1), we found that pH1N1-specific T cells showed cross- but biased reactivity to human-infecting AIVs, i.e., H5N1, H6N1, H7N9, and H9N2, which correlates with distinct protections. Through a T-cell epitope-based phylogenetic analysis, the cellular immunogenic clustering expanded the relevant conclusions to a broader range of virus strains. We defined the potential key conserved epitopes required for cross-protection and revealed the molecular basis for the immunogenic variations. Our study elucidated an overall profile of cross-reactivity to AIVs and provided useful recommendations for broad-spectrum vaccine development.IMPORTANCE We revealed preexisting but biased T-cell reactivity of pH1N1 influenza virus to human-infecting AIVs, which provided distinct protections. The cross-reactive T-cell recognition had a regular pattern that depended on the T-cell epitope matrix revealed via bioinformatics analysis. Our study elucidated an overall profile of cross-reactivity to AIVs and provided useful recommendations for broad-spectrum vaccine development. |
| Starting Page | 223 |
| Ending Page | 263 |
| Page Count | 41 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 30087171v1 |
| Alternate Webpage(s) | https://doi.org/10.1128/mBio.01408-18 |
| DOI | 10.1128/mbio.01408-18 |
| Journal | mBio |
| Volume Number | 9 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aves Cellular Phone Chronic Lymphocytic Leukemia Cross Reactions Epitopes Influenza A Virus, H1N1 Subtype Influenza in Birds Influenza virus vaccine Murine sarcoma viruses Orthomyxoviridae T-Lymphocyte statistical cluster vaccine development |
| Content Type | Text |
| Resource Type | Article |
