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The t(8;14) breakpoint of the EW 36 undifferentiated lymphoma cell line lies 5' of MYC in a region prone to involvement in endemic Burkitt's lymphomas.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tsujimoto, Yoshihide |
| Copyright Year | 1988 |
| Abstract | One of the best analyzed tumor-specific cytogenetic abnormalities is the t(8;14) chromosomal translocation observed in cases of Burkitt's and undifferentiated lymphomas (ULs), and acute lymphoblastic leukemias (ALLs). Here we analyze the cloned (8;14) chromosomal breakpoint of the UL cell line EW 36. We show that the region of chromosome 8 involved in the translocation is situated near a site previously demonstrated to harbor a cluster of endemic Burkitt's lymphoma breakpoints, approximately 50 kb 5' of MYC. In those cases, we demonstrated that malfunction of the V-D-J recombinase generated the translocations. However, in this case the isotype switch mechanism of translocation is implicated: at the breakpoint, S mu/S gamma and C gamma sequences are found on chromosome 14. Thus, the features of the EW 36 t(8;14) breakpoint are consonant with our model for B-cell lymphomagenesis which relates the precursor cell that gives rise to malignancy, the mechanism of translocation, and the phenotype of the tumor. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/16/5/10.1093_nar_16.5.2077/2/16-5-2077.pdf?Expires=1492230956&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=RJAIqULJ8mmW-3Nw6zgJHwB8xAFWDA02EzMvQNgq2YCrqb-csxDvSLg6JgZHC6U9dnsOSd3Hm5-vfpQCp8xIDxKrKKWmtmoVXlD3r8fr-oNyXQVvoNmRgPQ1OD0ePvJrPpjzNSTEYKjvmowQAH9uRP-6G8cYqXM7rgwJ3aoo452Qb2l040GwcZ6iFIesTjQ6wW8l1q5tT-84xYv1U3ene1MM9gFskRXzsEskHDwCdBPjJUb6XCON9XQnx7-tU-ij02uu9uW3swcnQOCeq0eoZ4qvR2jXJc88wjfJicCISUO-2H8VO~hZ6-BP0mVqYWd9JYEgA1t650Fn2Gjnab1vkw__ |
| PubMed reference number | 3128772v1 |
| Volume Number | 16 |
| Issue Number | 5 |
| Journal | Nucleic acids research |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acute lymphocytic leukemia Burkitt Lymphoma Chromosomal translocation Chromosome Aberrations Chromosomes, Human, Pair 8 Congenital Abnormality Hematopoietic stem cells Immunoglobulin Isotypes Intersex Leukemia, B-Cell Leukemogenesis Lymphoma, Non-Hodgkin Lymphoma, Undifferentiated Neoplasms Proto-Oncogene Proteins c-myc t(8;14) |
| Content Type | Text |
| Resource Type | Article |
