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Tracking Alzheimer's disease.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chiang, Ming-Chang Zubicaray, Greig I. De Aizenstein, H. J. |
| Copyright Year | 2007 |
| Abstract | Population-based brain mapping provides great insight into the trajectory of aging and dementia, as well as brain changes that normally occur over the human life span. We describe three novel brain mapping techniques, cortical thickness mapping, tensor-based morphometry (TBM), and hippocampal surface modeling, which offer enormous power for measuring disease progression in drug trials, and shed light on the neuroscience of brain degeneration in Alzheimer's disease (AD) and mild cognitive impairment (MCI). We report the first time-lapse maps of cortical atrophy spreading dynamically in the living brain, based on averaging data from populations of subjects with Alzheimer's disease and normal subjects imaged longitudinally with MRI. These dynamic sequences show a rapidly advancing wave of cortical atrophy sweeping from limbic and temporal cortices into higher-order association and ultimately primary sensorimotor areas, in a pattern that correlates with cognitive decline. A complementary technique, TBM, reveals the 3D profile of atrophic rates, at each point in the brain. A third technique, hippocampal surface modeling, plots the profile of shape alterations across the hippocampal surface. The three techniques provide moderate to highly automated analyses of images, have been validated on hundreds of scans, and are sensitive to clinically relevant changes in individual patients and groups undergoing different drug treatments. We compare time-lapse maps of AD, MCI, and other dementias, correlate these changes with cognition, and relate them to similar time-lapse maps of childhood development, schizophrenia, and HIV-associated brain degeneration. Strengths and weaknesses of these different imaging measures for basic neuroscience and drug trials are discussed. |
| Starting Page | 183 |
| Ending Page | 214 |
| Page Count | 32 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://users.loni.usc.edu/~thompson/PDF/Thompson-AD-NYAS-v8-Jul24.pdf |
| Alternate Webpage(s) | http://www.utdallas.edu/~tres/papers/thompson.2007.pdf |
| Alternate Webpage(s) | http://www.loni.ucla.edu/~thompson/PDF/Thompson-AD-NYAS-v8-Jul24.pdf |
| PubMed reference number | 17413023v1 |
| Volume Number | 1097 |
| Journal | Annals of the New York Academy of Sciences |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alzheimer's Disease Amyloidosis Atrophic Biological Markers Brain Mapping Cerebral atrophy Cerebral cortex Cerebral degeneration Child Development Cognition Disorders Complement System Proteins Dementia Diffusion Tensor Imaging Memory Disorders Microtubule-Associated Proteins Mild cognitive disorder Morphometric analysis Mucin 5AC Neurodegenerative Disorders Neurofibrillary degeneration (morphologic abnormality) Neuroimaging Neuroscience discipline Numerous Patients Plaque, Amyloid Progressive Disease Schizophrenia Senile Plaques Sensorimotor Cortex Serotonin Uptake Inhibitors Span Distance Temporal Lobe Therapeutic Clinical Trial Tracer Weakness glucose metabolism nervous system disorder secretase |
| Content Type | Text |
| Resource Type | Article |
