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Hippocampal neurofibrillary tangle changes and aggressive behaviour in dementia.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lai, Mitchell K. P. Chen, Christopher Hope, Tony Esiri, Margaret M. |
| Copyright Year | 2010 |
| Abstract | Neuropsychiatric behaviours occur frequently in Alzheimer's disease and other dementias and are thought to arise from the neurodegenerative process. However, it is unclear whether neurodegenerative changes in the hippocampus are associated with neuropsychiatric behaviours such as aggression. In this study, semiquantitative measurements of cell loss, atrophy, neuritic plaque and neurofibrillary tangle load in the postmortem hippocampus were taken for dementia patients, prospectively assessed for neuropsychiatric behaviours. It was found that increased tangle load, but not other hippocampal neuropathological variables, was associated with increased severity of aggressive behaviours and presence of chronic aggression. This study suggests a pathogenic link between neurofibrillary tangle load and aggressive behaviours in the hippocampus of dementia patients. |
| Starting Page | 51 |
| Ending Page | 74 |
| Page Count | 24 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.nuhs.edu.sg/wbn/slot/u3654/Yr%202010_4%201.pdf |
| PubMed reference number | 20890229v1 |
| Alternate Webpage(s) | https://doi.org/10.1097/WNR.0b013e3283407204 |
| DOI | 10.1097/wnr.0b013e3283407204 |
| Journal | Neuroreport |
| Volume Number | 21 |
| Issue Number | 17 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aggressive behavior Alzheimer's Disease Autopsy Dementia Neurofibrillary degeneration (morphologic abnormality) Passive-Aggressive Personality Disorder Patients Senile Plaques |
| Content Type | Text |
| Resource Type | Article |
