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Long-term low-dose angiotensin converting enzyme inhibitor treatment increases vascular cyclic guanosine 3',5'-monophosphate.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gohlke, Peter Lamberty, V. Kuwer, Ingo Bartenbach, S. Schnell, Andrea Linz, Wolfram Wiemer, Gabriele Unger, Thomas |
| Copyright Year | 1993 |
| Abstract | We investigated functional changes in aortic preparations of spontaneously hypertensive rats treated in utero and subsequently up to 20 weeks of age with the angiotensin converting enzyme (ACE) inhibitors ramipril (0.01 and 1 mg/kg per day) and perindopril (0.01 mg/kg per day). Early-onset treatment with the high dose of ramipril inhibited aortic ACE activity, prevented the development of hypertension, increased aortic vasodilator responses to acetylcholine (10(-8) to 10(-6) mol/L), decreased vasoconstrictor responses to norepinephrine (10(-8) mol/L), and increased aortic cyclic GMP content by 160%. Low-dose ramipril inhibited aortic ACE activity and attenuated the aortic vasoconstrictor response to norepinephrine but had no effect on blood pressure. Low-dose treatment with ramipril and perindopril resulted in a significant increase in aortic cyclic GMP content by 98% and 77%, respectively. Long-term coadministration of the bradykinin B2-receptor antagonist Hoe 140 abolished the ACE inhibitor-induced increase in aortic cyclic GMP. Our data demonstrate that long-term treatment with ACE inhibitors can alter vascular function of compliance vessels independently of the antihypertensive action. The increase in aortic cyclic GMP was due to bradykinin potentiating the action of the ACE inhibitors. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/22/5/682.full.pdf?download=true |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/22/5/682.full.pdf |
| PubMed reference number | 8225528v1 |
| Volume Number | 22 |
| Issue Number | 5 |
| Journal | Hypertension |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 3',5'-Cyclic-GMP Phosphodiesterases Acetylcholine Angiotensin-Converting Enzyme Inhibitors Angiotensins Antihypertensive Agents Aortic Valve Stenosis Blood Vessel Bradykinin Cyclic GMP DUOXA1 gene Guanosine Monophosphate Hypertensive disease Norepinephrine Perindopril Ramipril Uterus Vasoconstrictor Agents Vasodilator Agents |
| Content Type | Text |
| Resource Type | Article |
