NDLI: Structure and in vitro function of human subcutaneous small arteries in mild heart failure.

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Structure and in vitro function of human subcutaneous small arteries in mild heart failure.

Content Provider	Semantic Scholar
Author	Stephens, Natalie Hall, Alistair Scott Heagerty, Anthony M.
Copyright Year	1998
Abstract	The structure and function of subcutaneous small arteries from patients with mild heart failure (n = 27) 6-43 mo after myocardial infarction were compared with vessels from healthy control subjects (n = 10). Patients were randomized to treatment with placebo or the angiotensin-converting enzyme inhibitor ramipril starting 3-10 days after myocardial infarction. Dissected arterial vessels were mounted on a wire myograph for measurement of morphology and isometric tension. Morphology was not different in arteries from the three groups. Responses to norepinephrine, angiotensin II, and electrical field stimulation were similar in arteries from placebo-treated patients with mild heart failure and control subjects. Similarly, endothelium-dependent and -independent relaxation was normal in arteries from patients with mild heart failure. Ramipril therapy was associated with functional alterations: vasoconstrictor responses to norepinephrine and angiotensin II were significantly enhanced compared with placebo (P < 0.001). These data suggest that vascular structure and function are not different in vitro in subcutaneous arteries from placebo-treated patients with mild heart failure. Angiotensin-converting enzyme inhibitor therapy is associated with enhanced vasoconstriction to norepinephrine and angiotensin II, which may reflect upregulation of receptor-mediated events.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ajpcell.physiology.org/content/ajpcell/274/5/C1298.full.pdf
PubMed reference number	9612217v1
Volume Number	274
Issue Number	5
Part	1
Journal	The American journal of physiology
Language	English
Access Restriction	Open
Subject Keyword	Angiotensin II Angiotensin-Converting Enzyme Inhibitors Angiotensins Arterial system Arteries Blood Vessel Cerebrovascular Disorders Heart failure Myocardial Infarction Norepinephrine Patients Ramipril Tension Up-Regulation (Physiology) Vascular constriction (function) Vasoconstrictor Agents
Content Type	Text
Resource Type	Article

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