Loading...
Please wait, while we are loading the content...
Similar Documents
Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ha, Hongchien Snyder, Solomon H. |
| Copyright Year | 1999 |
| Abstract | Apoptotic and necrotic cell death are well characterized and are influenced by intracellular ATP levels. Poly(ADP-ribose) polymerase (PARP), a nuclear enzyme activated by DNA strand breaks, physiologically participates in DNA repair. Overactivation of PARP after cellular insults can lead to cell death caused by depletion of the enzyme's substrate beta-nicotinamide adenine dinucleotide and of ATP. In this study, we have differentially elicited apoptosis or necrosis in mouse fibroblasts. Fibroblasts from PARP-deficient (PARP(-/-)) mice are protected from necrotic cell death and ATP depletion but not from apoptotic death. These findings, together with cell death patterns in PARP(-/-) animals receiving other types of insults, indicate that PARP activation is an active trigger of necrosis, whereas other mechanisms mediate apoptosis. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.pnas.org/content/96/24/13978.full.pdf |
| PubMed reference number | 10570184v1 |
| Volume Number | 96 |
| Issue Number | 24 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adenosine Triphosphate Apoptosis Cell Death Cessation of life DNA Repair Dinucleoside Phosphates Mediator brand of benfluorex hydrochloride Necrosis Niacin Nicotinamide adenine dinucleotide (NAD) PARP1 protein, human Poly(ADP-ribose) Polymerases Ribose beta Thalassemia negative regulation of NAD+ ADP-ribosyltransferase activity |
| Content Type | Text |
| Resource Type | Article |
