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Incidence, risk factors, and clinical sequelae of angiographic peri-stent contrast staining after sirolimus-eluting stent implantation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Imai, Masao Kadota, Kazushige Goto, Tsuyoshi Fujii, Satoki Yamamoto, Hiroyuki Fuku, Yasushi Hosogi, Shingo Hirono, Akitoshi Tanaka, Hiroyuki Tada, Takeshi Morimoto, Tatsuya Shiomi, Hiroki Kozuma, Ken Inoue, Katsumi Noriyuki, Suzuki Kimura, Takeshi Mitsudo, Kazushige |
| Copyright Year | 2011 |
| Abstract | BACKGROUND We have noted abnormal angiographic findings--at the sites of drug-eluting stent implantation, suggesting contrast staining outside the stent struts--that do not fulfill the classic definition of coronary artery aneurysm. We propose a new term, peri-stent contrast staining (PSS), for these abnormal angiographic findings and assess their incidence, risk factors, and clinical sequelae. METHODS AND RESULTS Peri-stent contrast staining was defined as contrast staining outside the stent contour extending to ≥20% of the stent diameter. The study population consisted of 3081 lesions (1998 patients) that were treated exclusively with sirolimus-eluting stents and were evaluated by follow-up angiography within 12 months after sirolimus-eluting stent implantation in a single center. Late acquired PSS was observed in 58 lesions (1.9%) in 49 patients (2.5%). Independent risk factors of PSS included chronic total occlusion, whereas negative risk factors for PSS were left circumflex coronary artery lesion and in-stent restenosis lesion. Stent fracture was more frequently observed in lesions with PSS than in lesions without PSS (43.1% versus 5.4%, P<0.0001). Excluding 269 lesions with target-lesion revascularization within 12 months, the study population for long-term follow-up consisted of 51 lesions (42 patients) with PSS and 2761 lesions (1751 patients) without PSS. Cumulative incidence of target-lesion revascularization and definite very late stent thrombosis at 3 years in the PSS group was higher than that in the non-PSS group (15.0% versus 6.5%, and 8.2% versus 0.2%, respectively). CONCLUSIONS Peri-stent contrast staining found within 12 months after sirolimus-eluting stent implantation appeared to be associated with subsequent target-lesion revascularization and very late stent thrombosis. |
| Starting Page | 709 |
| Ending Page | 709 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/123/21/2382.full.pdf |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/123/21/2382.full.pdf?download=true |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/early/2011/05/16/CIRCULATIONAHA.110.003459.full.pdf?download=true |
| PubMed reference number | 21576652v1 |
| Alternate Webpage(s) | https://doi.org/10.1161/CIRCULATIONAHA.110.003459 |
| DOI | 10.1161/CIRCULATIONAHA.110.003459 |
| Journal | Circulation |
| Volume Number | 123 |
| Issue Number | 21 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Contrast Media Coronary Aneurysm Diameter (qualifier value) Drug-Eluting Stents Forty Nine Name Patients Sequela of disorder Sirolimus Staining method Stent Device Component Stent, device Structure of circumflex branch of left coronary artery Thrombosis angiogram restenosis revascularization |
| Content Type | Text |
| Resource Type | Article |
