NDLI: C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells: implications for the metabolic syndrome and atherothrombosis.

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C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells: implications for the metabolic syndrome and atherothrombosis.

Content Provider	Semantic Scholar
Author	Sridevi Devaraj Xu, Dan Yan Jialal, Ishwarlal
Copyright Year	2003
Abstract	BACKGROUND Inflammation plays a pivotal role in atherosclerosis. In addition to being a risk marker for cardiovascular disease, much recent data suggest that C-reactive protein (CRP) promotes atherogenesis via effects on monocytes and endothelial cells. The metabolic syndrome is associated with significantly elevated levels of CRP. Plasminogen activator inhibitor-1 (PAI-1), a marker of atherothrombosis, is also elevated in the metabolic syndrome and in diabetes, and endothelial cells are the major source of PAI-1. However, there are no studies examining the effect of CRP on PAI-1 in human aortic endothelial cells (HAECs). METHODS AND RESULTS Incubation of HAECs with CRP results in a time- and dose-dependent increase in secreted PAI-1 antigen, PAI-1 activity, intracellular PAI-1 protein, and PAI-1 mRNA. CRP stabilizes PAI-1 mRNA. Inhibitors of endothelial NO synthase, blocking antibodies to interleukin-6 and an endothelin-1 receptor blocker, fail to attenuate the effect of CRP on PAI-1. CRP additionally increased PAI-1 under hyperglycemic conditions. CONCLUSIONS This study makes the novel observation that CRP induces PAI-1 expression and activity in HAECs and thus has implications for both the metabolic syndrome and atherothrombosis.
Starting Page	398
Ending Page	404
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/107/3/398.full.pdf?download=true
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/107/3/398.full.pdf
Alternate Webpage(s)	http://circ.ahajournals.org/content/107/3/398.full.pdf
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/early/2003/01/06/01.CIR.0000052617.91920.FD.full.pdf
PubMed reference number	12551862v1
Volume Number	107
Issue Number	3
Journal	Circulation
Language	English
Access Restriction	Open
Subject Keyword	Antibodies, Blocking Atherosclerosis C-reactive protein Cardiovascular Diseases Cell secretion Diabetes Mellitus Endothelial Cells Endothelin-1 Receptor, Human Metabolic Syndrome X Nitric Oxide Synthase Plasminogen Activator Receptor, Endothelin A SERPINE1 protein, human Urokinase alteplase
Content Type	Text
Resource Type	Article

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