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Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sardi, Janaína De Cássia Orlandi Scorzoni, Liliana Bernardi, Thierry Fusco-Almeida, Ana Marisa Giannini, Maria José Soares Mendes |
| Copyright Year | 2013 |
| Abstract | The incidence of fungal infections has increased significantly, so contributing to morbidity and mortality. This is caused by an increase in antimicrobial resistance and the restricted number of antifungal drugs, which retain many side effects. Candida species are major human fungal pathogens that cause both mucosal and deep tissue infections. Recent evidence suggests that the majority of infections produced by this pathogen are associated with biofilm growth. Biofilms are biological communities with a high degree of organization, in which micro-organisms form structured, coordinated and functional communities. These biological communities are embedded in a self-created extracellular matrix. Biofilm production is also associated with a high level of antimicrobial resistance of the associated organisms. The ability of Candida species to form drug-resistant biofilms is an important factor in their contribution to human disease. The study of plants as an alternative to other forms of drug discovery has attracted great attention because, according to the World Health Organization, these would be the best sources for obtaining a wide variety of drugs and could benefit a large population. Furthermore, silver nanoparticles, antibodies and photodynamic inactivation have also been used with good results. This article presents a brief review of the literature regarding the epidemiology of Candida species, as well as their pathogenicity and ability to form biofilms, the antifungal activity of natural products and other therapeutic options. |
| Starting Page | 10 |
| Ending Page | 24 |
| Page Count | 15 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.antibodychain.com/printpdf/45703 |
| Alternate Webpage(s) | http://www.microbiologyresearch.org/docserver/fulltext/jmm/62/1/10_jmm045054.pdf?accname=guest&checksum=739EE81635084D2B4DB548A5DDE071AC&expires=1542879339&id=id |
| Alternate Webpage(s) | http://www.microbiologyresearch.org/docserver/fulltext/jmm/62/1/10_jmm045054.pdf?accname=guest&checksum=3EB6BB52C9B59DC8FB337C998286F26F&expires=1540764304&id=id |
| Alternate Webpage(s) | http://www.microbiologyresearch.org/docserver/fulltext/jmm/62/1/10_jmm045054.pdf?accname=guest&checksum=9F93647E7EC711512CFCE737783DEA9B&expires=1542045713&id=id |
| Alternate Webpage(s) | http://www.microbiologyresearch.org/docserver/fulltext/jmm/62/1/10_jmm045054.pdf?accname=guest&checksum=A8ED09924D76EC42876F6ED1E80FD980&expires=1539419954&id=id |
| PubMed reference number | 23180477v1 |
| Alternate Webpage(s) | https://doi.org/10.1099/jmm.0.045054-0 |
| DOI | 10.1099/jmm.0.045054-0 |
| Journal | Journal of medical microbiology |
| Volume Number | 62 |
| Part | 1 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antifungal Agents Biological Community Biological Factors Body tissue Candida albicans reaction wheal^1D post 50 ug Candida albicans ID:Diam:Pt:Skin:Qn Critical Illness Drug Discovery Embedding Extracellular Matrix Infection Mastocytosis, Systemic Medical Devices Microbial Biofilms Microorganism Morbidity - disease rate Mucous Membrane Mycoses Natural Products Pathogenic organism Pathogenicity Patients Silver Therapeutic procedure negative regulation of reactive oxygen species biosynthetic process |
| Content Type | Text |
| Resource Type | Article |
