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Modeling of counter current monoclonal antibody extraction using aqueous two-phase systems
| Content Provider | Semantic Scholar |
|---|---|
| Author | Samatou, Joachim Ahmed Wentink, Annebart Engbert Rosa, P. A. J. Azevedo, Ana Margarida Aires-Barros, Maria Raquel Bäcker, Werner Górak, Andrzej |
| Copyright Year | 2007 |
| Abstract | Abstract Design of chemical processes is usually based on rigorous modeling of unit operations. Unfortunately, the use of physically grounded models in biotechnological applications is rare since their design is mainly based on heuristics and experiments. In this work a computer aided design method is presented for modeling of aqueous two-phase extraction of monoclonal antibodies (MAbs). A conventional counter current extractor is compared with a fractional extractor in terms of purity and concentration of MAbs in the extract. The purity of MAbs increased from 85% in the conventional to almost 100% in the fractional extractor. |
| Starting Page | 935 |
| Ending Page | 940 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S1570-7946(07)80180-5 |
| Volume Number | 24 |
| Alternate Webpage(s) | http://www.nt.ntnu.no/users/skoge/prost/proceedings/escape17/papers/T4-244.pdf |
| Alternate Webpage(s) | http://folk.ntnu.no/skoge/prost/proceedings/escape17/papers/T4-244.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/S1570-7946%2807%2980180-5 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
