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Endometrial LGR7 expression and implantation failure.

Content Provider	Semantic Scholar
Author	Campitiello, Maria Rosaria Caprio, Francesca Mele, Daniela D'eufemia, Diletta Colacurci, Nicola Franciscis, Pasquale De
Copyright Year	2016
Abstract	Implantation failure is considered as a major cause of infertility in women with recurrent pregnancy loss (RPL) and in otherwise healthy women with unexplained infertility. Preliminary data in primates suggested that relaxin (RLX) is involved in endometrial preparation for implantation. In a prospective observational study, the endometrial RLX receptor (LGR7) expression was assessed in three groups of patients with regular ovulatory cycle and normal uterine cavity: 23 with RPL (Group A), 23 with unexplained infertility undergone at least three cycles of failed in vitro fertilization (IVF) reporting good oocyte and embryo quality (Group B), 23 with proven fertility (Group C). Assessment of LGR7 expression was performed with both polymerase chain reaction (PCR) analysis and immunohistochemistry on endometrial samples obtained with hysteroscopic biopsy performed in the secretory phase of the menstrual cycle. Endometrial LGR7 was less expressed in group A and B versus C, both by PCR analysis (p = 0.024) and immunohistochemistry. The decreased expression of the endometrial RLX receptor in women with implantation failures, both in vitro fertilization failure and recurrent pregnancy loss, suggests that RLX may play a crucial role in the structural and functional changes of the endometrium during the window of implantation.
Starting Page	2513
Ending Page	2518
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://centroinfertilitasun.it/wp-content/uploads/2016/02/selection.pdf
PubMed reference number	26761440v1
Alternate Webpage(s)	https://doi.org/10.3109/09513590.2015.1127912
DOI	10.3109/09513590.2015.1127912
Journal	Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Volume Number	32
Issue Number	6
Language	English
Access Restriction	Open
Subject Keyword	Cell secretion Dental caries Endometrial Neoplasms Endometrium Female infertility Fertility Agents Fertilization in Vitro Heart failure Infertility study Liver Failure, Acute Menstrual cycle Menstruation Oocytes Patients Polymerase Chain Reaction Primates Recurrent pregnancy loss Relaxin Uterine Corpus Carcinosarcoma Uterus
Content Type	Text
Resource Type	Article

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