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DNA rearrangements in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tsujimoto, Yoshihide Bashir, Muhammad Mokarram Givol, Iris Cossman, Jeffrey Jaffe, E. Croce, Carlo M. |
| Copyright Year | 1987 |
| Abstract | In most human follicular lymphomas, the chromosome translocation t(14;18) occurs within two breakpoint clustering regions on chromosome 18, the major one at the 3' untranslated region of the bcl-2 gene and the minor one at 3' of the gene. Analysis of a panel of follicular lymphoma DNAs using probes for the first exon of the bcl-2 gene indicates that DNA rearrangements may also occur 5' to the involved bcl-2 gene. In this case the IgH locus and the bcl-2 gene are found in the order 3' C gamma S gamma/mu JH 5'::5' bcl-2 3' (where C = constant, S = switch, and JH = joining segment of the heavy chain locus), suggesting that an inversion also occurred during the translocation process. The coding regions of the bcl-2 gene, however, are left intact in all cases of follicular lymphoma studied to date. |
| Starting Page | 895 |
| Ending Page | 903 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.pnas.org/content/84/5/1329.full.pdf |
| PubMed reference number | 3547408v1 |
| Volume Number | 84 |
| Issue Number | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 3' Untranslated Regions BCL2 gene BCL2 wt Allele Chromosomal translocation Chromosomes, Human, Pair 18 DNA Sequence Rearrangement Interferon Type II Lymphoma Lymphoma, Follicular SLC3A2 gene statistical cluster t(14;18) |
| Content Type | Text |
| Resource Type | Article |
