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Monitoring of immunity against leukemia stem cell in CML patients after cessation of TKI
| Content Provider | Semantic Scholar |
|---|---|
| Author | Matsushita, Maiko Ozawa, Koji Kanchi, Saori Uchiumi, Akane Suzuki, Takuma Ichikawa, Daiju Matsuki, Eri Sakurai, Masatoshi Karigane, Daiki Kasahara, Hidenori Nakajima, Hideaki Okamoto, Shinichiro Hattori, Yutaka |
| Copyright Year | 2015 |
| Abstract | Purpose Tyrosine kinase inhibitors (TKIs) have improved overall survival of patients with chronic myeloid leukemia (CML). Moreover, it has been reported that some of the patients achieve treatment-free remission (TFR) after cessation of TKIs, even though leukemic stem cells (LSC) of CML are considered to be resistant to TKIs. Therefore, these findings suggest that remaining LSCs could be eradicated by immune system after withdrawal of TKIs. In order to clarify the role of anti-LSC immunity in achieving TFR, we tried to detect cytotoxic T cells against one of the LSC antigens, KU-MEL9 in CML patients. |
| Starting Page | P260 |
| Ending Page | P260 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://jitc.biomedcentral.com/track/pdf/10.1186/2051-1426-3-S2-P260 |
| PubMed reference number | 4649342 |
| Volume Number | 3 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acute Undifferentiated Leukemia Chronic electrode implant Immune system Myeloid Leukemia Myeloid Leukemia, Chronic Patients Stem cells Tyrosine Kinase Inhibitors [MoA] |
| Content Type | Text |
| Resource Type | Article |
