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Antidiabetic and Anti-oxidative Effects of Honokiol on Diabetic Rats Induced by High-fat Diet and Streptozotocin
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, Junjun Zhao, Rong Liang, Ji-Chao Chen, Yong |
| Copyright Year | 2014 |
| Abstract | 10.1016/S1674-6384(14)60005-8 Objective To study the antidiabetic and anti-oxidative effects of honokiol (Hon) in Magnolia officinalis and its underlying molecular mechanism in diabetic rats induced by high-fat diet (HFD) and streptozotocin (STZ). Methods After ig administration with Hon [25, 50, and 100 mg/(kg·d)] to diabetic rats for consecutive 10 weeks, the levels of blood glucose (BG), oral glucose tolerance (OGT), blood lipids including total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), and low density lipoprotein-cholesterol (LDL-C), hepatic oxidative stress including the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), methane dicarboxylic aldehyde (MDA), and cytochrome P4502E1 (CYP2E1) in diabetic rats were measured. Results Compared to the diabetic control rats, ig administration of Hon resulted in significant decrease in BG, TC, TG, and LDL-C levels in serum, as well as hepatic CYP2E1 activity and MDA content in diabetic rats, whereas the level of OGT and activities of hepatic CAT, SOD, and GSH-Px in diabetic rats were significantly increased. Conclusion Hon could alleviate hyperglycemia, hyperlipemia, hepatic oxidative damage, and insulin resistance in diabetic rats by inhibiting hepatic CYP2E1 activity. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.tiprpress.com/chmen/ch/reader/create_pdf.aspx?falg=1&file_no=CHM201401005&quarter_id=1&year_id=2014 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 3,4-Methylenedioxyamphetamine Acetaldehyde Antidiabetics Betaine-aldehyde dehydrogenase Blood substitute CATALASE Cat-Scratch Disease Cholesterol Diabetes Mellitus Diet, High-Fat GLUTATHIONE PEROXIDASE Hardware Freedom Day Hardware description language Hematological Disease High Density Lipoproteins Hyperglycemia Hyperlipidemia Immune Tolerance Immunoglobulins Inhibition Insulin Resistance Job control (Unix) Liver diseases Low-Density Lipoproteins Magnolia officinalis Oral Glucose Tolerance Test Oxidative Stress Streptozocin Superoxide Dismutase Superoxides Triglycerides honokiol |
| Content Type | Text |
| Resource Type | Article |
