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Concentrations of copper and zinc in liver and serum samples in biliary atresia patients at different stages of traditional surgeries.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sato, Chiharu Koyama, Hiroshi Satoh, Hiroshi Hayashi, Yutaka Chiba, Tsuneo Ohi, Ryoji |
| Copyright Year | 2005 |
| Abstract | Many patients with biliary atresia (BA) have impaired metabolism of copper (Cu) and zinc (Zn) because of the obstruction of bile ducts. An excessive Cu accumulation is cytotoxic and results in fibrosis in hepatic tissues. Since Zn works antagonistically to Cu, lower Zn concentrations may deteriorate liver damage. In the 1980's, we performed a series of surgeries on BA patients for the construction and alteration of the bile flow route, which is the major excretion route for Cu. We obtained liver and serum samples at each surgery, and measured Cu and Zn concentrations by inductively coupled plasma atomic emission spectrometry. Hepatic Cu concentration decreased with the improvement of cholestasis after the establishment of bile excretion. Conversely, when cholestasis persisted or recurred, increases in hepatic and serum Cu concentrations were noted. Hepatic Zn concentration was lower than previously reported normal values. High hepatic and serum Cu concentrations due to persistent or recurrent cholestasis and low hepatic Zn concentration may deteriorate hepatic fibrosis and liver cirrhosis. |
| Starting Page | 196802 |
| Ending Page | 196802 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.journal.med.tohoku.ac.jp/2074/TJ2074_05.pdf |
| PubMed reference number | 16272797v1 |
| Volume Number | 207 |
| Issue Number | 4 |
| Journal | The Tohoku journal of experimental medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bile duct structure Bile fluid Biliary Atresia Body tissue Chemical and Drug Induced Liver Injury Cholestasis Copper Curcumin Duct (organ) structure Echinococcosis, Hepatic Fibrosis Fibrosis, Liver Impatent structure Liver Cirrhosis Liver diseases Obstruction Operative Surgical Procedures Patients Spectrometry Spectrometry, X-Ray Emission |
| Content Type | Text |
| Resource Type | Article |
