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Long-term prognosis for infants with intrahepatic cholestasis and patent extrahepatic biliary tract.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Odiévre, Michel Hadchouel, Michelle Landrieu, Pierre Georges Alagille, Daniel |
| Copyright Year | 1981 |
| Abstract | One hundred and three infants with prolonged cholestasis beginning before 3 months were classified as having alpha-1-antitrypsin deficiency (17 patients), scanty interlobular bile ducts (16 patients), or "neonatal hepatitis" (70 patients). Twenty-two gradually developed chronic liver disease and the remaining 81 recovered within a few months. Prognosis was found to be poor for infants with alpha-1-antitrypsin deficiency, scanty interlobular bile ducts, and familial "idiopathic" hepatitis. Patients who developed cirrhosis often presented with severe and persistent neonatal cholestasis, mimicking extrahepatic biliary atresia and leading to laparotomy. Thus, a high-risk group of infants-defined by aetiology, family history, and degree of cholestasis-can be recognised in the first months of life. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://adc.bmj.com/content/archdischild/56/5/373.full.pdf |
| PubMed reference number | 6973322v1 |
| Volume Number | 56 |
| Issue Number | 5 |
| Journal | Archives of disease in childhood |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bile duct structure Biliary Atresia Biliary tract structure Chemical and Drug Induced Liver Injury Classification Duct (organ) structure Fibrosis Forecast of outcome Giant cell hepatitis Hyperlipoproteinemia Type I Impatent structure Interlobular bile duct Intrahepatic Cholestasis Laparotomy Liver diseases Patients alpha 1-Antitrypsin Deficiency chronic liver disease |
| Content Type | Text |
| Resource Type | Article |