Loading...
Please wait, while we are loading the content...
Similar Documents
Neoadjuvant chemotherapy for resectable esophageal carcinoma: a meta-analysis of randomized clinical trials.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Xu, Xiao-Hua Peng, Xiaoqing Yu, Ping Xu, Xiao-Yuan Cai, E. Guo, Pi |
| Copyright Year | 2012 |
| Abstract | Neoadjuvant chemotherapy for resectable esophageal carcinoma has been a focus of study, but no agreement has been reached on clinical randomized controlled trials and relevant systematic evaluation. The purpose of this study was to perform a meta-analysis on published randomized controlled trials (RCTs) that compared neoadjuvant chemotherapy and surgery with surgery alone for resectable esophageal carcinoma. Medline and manual searches was conducted in PubMed, ASCO (American Society of Clinical Oncology) meeting summary, Embase, the Cochrane Library (up to October 2010), Chinese Biomedical Literature Database, China National Knowledge Infrastructure, VIP Database, Wanfang Database. The selection contents were to identify all published and unpublished RCTs that compared neoadjuvant chemotherapy and surgery with surgery alone for resectable esophageal carcinoma. Sixteen RCTs which included 2,594 patients were selected. The risk ratio (RR) (95% confidence interval [CI]; P value), expressed as neoadjuvant chemotherapy and surgery versus surgery alone (treatment versus control), was 1.02 (0.95, 1.10; P=0.54) for 1-year survival, 1.29 (1.13, 1.47; P=0.0001) for 3-year survival, 1.31 (1.13, 1.51; P=0.0003) for 5-year survival, 1.00 (0.95, 1.04; P= 0.85) for rate of resection and 0.89 (0.64, 1.23; P=0.48) for operative mortality. The results showed that neoadjuvant chemotherapy for resectable esophageal carcinoma can raise the overall survival rate of patients with esophageal carcinoma, but it does not affect treatment-related mortality. |
| Starting Page | M12 |
| Ending Page | M12 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://apjcpcontrol.net/paper_file/issue_abs/Volume13_No1/103-110%2012.5%20Xiao-Hua%20Xu.pdf |
| Alternate Webpage(s) | http://ocean.kisti.re.kr/downfile/volume/apocp/POCPA9/2012/v13n1/POCPA9_2012_v13n1_103.pdf |
| PubMed reference number | 22502650v1 |
| Volume Number | 13 |
| Issue Number | 1 |
| Journal | Asian Pacific journal of cancer prevention : APJCP |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | American Society of Clinical Oncology Confidence Intervals Esophageal carcinoma Excision Neoadjuvant Therapy Overall Survival Patients Randomized Controlled Trials as Topic Scientific Publication contents - HtmlLinkType |
| Content Type | Text |
| Resource Type | Article |
