NDLI: Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc05040b

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Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc05040b

Content Provider	Semantic Scholar
Author	Robke, Lucas Futamura, Yushi Konstantinidis, Georgios Wilke, Julian Aono, Harumi Mahmoud, Zhwan Watanabe, Nobumoto Wu, Yao-Wen Osada, Hiroyuki Laraia, Luca Waldmann, Herbert
Copyright Year	2018
Abstract	Macroautophagy is a conserved eukaryotic process for degradation of cellular components in response to lack of nutrients. It is involved in the development of diseases, notably cancer and neurological disorders including Parkinson's disease. Small molecule autophagy modulators have proven to be valuable tools to dissect and interrogate this crucial metabolic pathway and are in high demand. Phenotypic screening for autophagy inhibitors led to the discovery of the novel autophagy inhibitor aumitin. Target identification and confirmation revealed that aumitin inhibits mitochondrial respiration by targeting complex I. We show that inhibition of autophagy by impairment of mitochondrial respiration is general for several mitochondrial inhibitors that target different mitochondrial complexes. Our findings highlight the importance of mitochondrial respiration for autophagy regulation.
Starting Page	3014
Ending Page	3022
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1039/c7sc05040b
PubMed reference number	29732085
Journal	Medline
Volume Number	9
Alternate Webpage(s)	http://umu.diva-portal.org/smash/get/diva2:1315190/FULLTEXT01.pdf
Alternate Webpage(s)	http://www.rsc.org/suppdata/c7/sc/c7sc05040b/c7sc05040b1.pdf
Alternate Webpage(s)	https://pubs.rsc.org/en/content/articlepdf/2018/sc/c7sc05040b
Alternate Webpage(s)	https://doi.org/10.1039/c7sc05040b
Journal	Chemical science
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc05040b

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