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Mir-145-5p Functions As A Tumor Suppressor In Nonfunctioning Pituitary Adenoma By Regulating TPT1-Mcl-1/Bcl-Xl/Bax Pathway
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhu, Yonghong Wang, Haijun |
| Copyright Year | 2018 |
| Abstract | Results Our results showed that miR-145-5p was markedly decreased in NFPAs samples and cell lines, and negatively associated with the invasiveness of NFPAs. Overexpression of miR-145-5p resulted in a significant reduction of cell proliferation, migration, invasion, colony formation, and in vivo tumor growth. Through bioinformatics analysis and dual luciferase assays, translationally controlled tumor protein (TPT1) was identified as a novel direct target of miR-145-5p. Concurrent experiments demonstrated that miR-145-5p induced cell apoptosis by targeting TPT1, sequentially downregulating Mcl-1/Bcl-xL and upregulating Bax. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://wfns-symposia2018.com/Abstract/Oral_Presentations/Day2_Lecture_Hall_D1/Cellular_&_Molecular_biology_and_genetics_and_targeted_precision_therapy/FC08.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
