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MiR-145 functions as a tumor suppressor in Papillary Thyroid Cancer by inhibiting RAB5C.
| Content Provider | Europe PMC |
|---|---|
| Author | Zhang, Wei Ji, Wenyue Li, Tianshu Liu, Ting Zhao, Xudong |
| Copyright Year | 2020 |
| Abstract | Papillary thyroid carcinoma (PTC) accounts for the largest proportion of thyroid cancers; and its morbidity rate has dramatically increased in recent decades. However, the pathogenesis mechanisms of PTC are still not clear. This study aimed to reveal that miR-145 acts as an antitumor miRNA in the progression of PTC. In the present study, the expression of miR-145 was analyzed in 57 paired PTC patient samples. The relationship between clinicopathological features and miR-145 expression were also defined. The tumor suppressive function of miR-145 on PTC cell metastasis, proliferation and apoptosis were revealed in vitro. Also, we used dual luciferase reporter assay to define the relationship of miR-145 and RAB5C. RAB5C was reported to participate in cell invasion and cell motility. We found that miR-145 was downregulated in PTCs, which was negatively correlated with PTC progression and metastasis. MiR-145 inhibited PTC migration, proliferation and promoted apoptosis by directly suppresing RAB5C. In conclusion, miR-145 functions as a tumor suppressor in PTC by inhibiting RAB5C. MiR-145 and RAB5C are potential therapeutic targets in therapy of aggressive PTC cases. |
| Journal | International Journal of Medical Sciences |
| Volume Number | 17 |
| PubMed Central reference number | PMC7415399 |
| Issue Number | 13 |
| PubMed reference number | 32788878 |
| e-ISSN | 14491907 |
| DOI | 10.7150/ijms.44723 |
| Language | English |
| Publisher | Ivyspring International Publisher |
| Publisher Date | 2020-07-25 |
| Publisher Place | Sydney |
| Access Restriction | Open |
| Rights License | This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. © The author(s) |
| Subject Keyword | miR-145 RAB5C papillary thyroid carcinoma PTC |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
