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Spectrophotometric Determination of Sulfathiazole Using 2,4 –dinitrophenylhydrazine as Coupling Reagent
| Content Provider | Semantic Scholar |
|---|---|
| Author | Humedy, Israa Talib Ali, Ismael |
| Copyright Year | 2017 |
| Abstract | A rapid, sensitive and selective spectrophotometric method was developed for determination of sulfathiazole (STHZ) in aqueous solution. The method is based on the oxidative coupling reaction with 2,4-dinitrophenylhydrazine (2,4-DNPH) in a basic medium (pH 10.9) in the presence of potassium periodate to produce an intense orange colour, soluble in water , stable product and absorbs at 492 nm. Beer's law was in the linear range 2.0-28.0 μg/ml of sulfathiazole, the molar absorptivity, Sandellʼs sensitivity index and detection limit were 1.1437 ×104 liter. mol-1.cm-1,0.0223 μg.cm-2 and 0.1274 μg/ml respectively. The RSD value was 0.75 - 1.12 % depending on the concentration. This method was applied successfully to the determination of sulfathiazole veterinary injection liquid solution (bio prime) with average recovery of not less than 100.38 %. |
| Starting Page | 227 |
| Ending Page | 239 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| Volume Number | 29 |
| Alternate Webpage(s) | http://uobaghdad.edu.iq/jih/index.php/j/article/download/112/96 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
