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Strong and Lubricious Poly(vinyl alcohol)-Polyacrylic Acid Hydrogels for Cartilage Resurfacing
| Content Provider | Semantic Scholar |
|---|---|
| Copyright Year | 2010 |
| Abstract | Introduction: Polyvinyl alcohol (PVA) hydrogels are one of the most studied biocompatible hydrogels for early stage osteochondral defect repair for their tunable mechanical strength, high water content and surface lubricity which resembles the natural cartilage. However, PVA hydrogel in its un-processed form lacks the strength and toughness to serve as a cartilage substitute material. Most researchers used thermal annealing to strengthen the hydrogel. While thermal annealing increases strength, it also decreases the water content and lubricity of the hydrogel. This is of particular concern as counterface cartilage is likely to be damaged with an increase in coefficient of friction. Addition of a non-volatile substance, such as low molecular weight polyethylene glycol, PEG [1], or the addition of a hydrophilic substance such as poly acrylic acid (PAA), could prevent pore collapse during annealing and as a result maintain loss of water content and lubricity [2,3]. The significance of these PVA formulations is that they could be used to delay the cascade of degeneration and delay more invasive surgical treatments in human joints. Incorporating PAA in the PVA network and doping with PEG resulted in very strong gels with high lubricity [3]. In this study we investigated the effect of rehydration media and compared deionized water (DI) to simulated body fluid (SBF) which contains equal amounts of sodium, potassium, magnesium, calcium, carbonate, phosphate, sulfate ions (Na, K, Mg, Ca, Cl, HCO, HPO4, SO4 ) at pH=7.4. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.ors.org/Transactions/57/2092.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
