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Bile Acids XIII. FURTHER CONTRIBUTIONS TO THE CONSTITUTION OF MURICHOLIC ACIDS
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sl, Hsia Elliott, William H. Matschiner, John T. Ea, Doisy Thayer, Sidney A. Doisy, Edward A. |
| Copyright Year | 1960 |
| Abstract | Our recent studies on the metabolism of bile acids led to the isolation of four new acids (l-3). Chemical studies and partial syntheses have established that three of these new acids are 3cu, 6,7-trihydroxycholanic acids, isomeric with hyocholic acid (3cy, 6cu, 7cr-trihydroxycholanic acid) which was isolated and named by Haslewood (4); it was also isolated and studied by Ziegler (5). Two of these new acids, Acid I (3a,6@,7/3-trihydroxycholanic acid) (6) and Acid II (3a, 6p, 7&rihydroxycholanic acid) (7), are normal constituents of rat bile (1) ; recently they have been found as metabolites of chenodeoxycholic-24-Cl4 acid in the bile of mice (8) and in the urine of surgically jaundiced mice.’ The fourth epimeric 6,7-glycol, Acid IV (3a, 6,) 7&trihydroxycholanic acid) (9), was isolated as a metabolite of hyodeoxycholic acid in the rat (2). In order to designate these new acids by trivial names more appropriate to their origin we have chosen the name “muricholic acids”2 from the Latin mus, muris, meaning rat or mouse. We propose to use the prefixes “a? and “@” to signify the orientation of the hydroxyl group at C-7; thus the 6/3,7cr-glycol (Acid II) is cY-muricholic acid, and the Sp ,7@-glycol (Acid I) is @-muricholic acid. The 6a ,7cu-glycol which we isolated from hog bile and referred to as Hog Acid was later shown to be identical with Haslewood’s hyocholic acid (4, 5, 10). For the fourth and last epimeric 6,7-glycol, Acid IV (60,7p) we propose the name, w-muricholic acid. This paper presents the results of additional chemical studies relevant to the structures of these acids and a comparison of some of their physical and chemical properties, |
| Starting Page | 1963 |
| Ending Page | 1967 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Volume Number | 235 |
| Alternate Webpage(s) | http://www.jbc.org/content/235/7/1963.full.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
