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Synthesis, Characterization and Antimicrobial Activity of 5,6-Dimethyl thieno[2,3-d]Pyrimidine Derivatives
| Content Provider | Semantic Scholar |
|---|---|
| Author | Patel, Himanshu D. Patel, Paresh S. Patel, Keshav C. |
| Copyright Year | 2018 |
| Abstract | Introduction Medicinal Chemistry essentially it concerns with the understanding of mechanisms of action of drugs mechanism. It attempts to establish relationship between structure and function (activity) and to link biodynamic behavior with chemical reactivity and physical properties. Chemists have a chance to participate in the fundamentals of prevention, therapy and understanding of diseases and thereby to contribute to a healthier and happier life” [1] . Thienopyrimidines are important class of fused heterocycles that are of considerable interest on account of diverse range of their biological activities [2] such as; antibiotic, radioprotective, anticancer, antimicrobial [3] , antiviral, antiproliferative, antifolate, antiamnesic, anaphylactic, antihistaminic, antiglaucoma, antioxidant, anticoccidial, thrombolytic, antifungal, neurotropic, molluscicidal and larvicidal, antipyretic, analgesic, antipsychotic, anticonvulsant, anti-inflammatory, ulcerogenic index, antihypertensive, antibacterial, antiallergic, antiarrhythmic, antidepressant [4-8] . Many thieno[2,3-d]pyrimidine derivatives were reported as phosphodiesterase inhibitors, also exhibit good H1 receptor antagonistic activities and 4-amino thienopyrimidine derivatives show insecticidal, pesticidal and acaricidal activities. Numerous thieno[2,3-d]pyrimidines have been proved useful for cerebral ischemia, malaria, tuberculosis, Alzheimer's and Parkinson's diseases [9] . Some thienopyrimidine derivatives have also found as fluorescent dyes for biomolecule detection and as novel ionophores in plasticized poly(vinyl chloride) matrix membrane sensors for uranyl ions [10] . Benzothiazole derivatives exhibit a wide range of biological activities [11-12] , Benzothiazole moiety exhibits activity such as antiallagesic, antiparastic, antitumour, antiglutamate, antifungal, vasdilator, anticancer, brest cancer, antitubercular, CNS, photosynthesis inhibiting activity, antiinflammatory, antibacterial [13-14] etc. Chalcones are natural compounds that are largely distributed in plants, fruits, and vegetables. They belong to the flavonoid group of molecules and some of them exhibit numerous biological activities. They are precursors in flavonoid biosynthesis. The enzymatic cyclization of the 6'-hydroxychalcones leads to the formation of flavanones and subsequently to a large number of flavonoid groups including flavones, flavonols, dihydroflavonols, aurones and isoflavones [15] . Chalcone moiety exhibits activity such as antiallagesic, antiparastic, antihypertensive, anti-inflammatory, antibacterial etc [16-18] . Experimental Chemical and instrumentation: This present work deals with the synthesis and studies of some thieno[2,3-d] pyrimidine derivatives 3(a-e) N-(substitutedbenzo[d]thiazol2-yl)-5,6-di methylthieno[2,3-d]pyrimidin-4-amine and 5(a-e) 3-(substituted phenyl)-1-(4-(5,6-dimethylthieno [2,3d]pyrimidin-4-ylamino)phenyl)prop-2-en-1-one have been synthesized from the key compound ethyl-2-amino-4,5dimethyl thiophene-3-carboxylate. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.elixirpublishers.com/articles/1519468731_ELIXIR2018016072.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
