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Correlates of plasma atrial natriuretic factor in health and hypertension.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Montorsi, P. Tonolo, Giancarlo Polónia, Jorge Hepburn, David A. Richards, Arthur Mark |
| Copyright Year | 1987 |
| Abstract | Plasma concentrations of atrial natriuretic factor (ANF) were compared in normotensive subjects and subjects with untreated, uncomplicated essential hypertension (n = 21 pairs) matched for age, sex, and race. Plasma peptide values were slightly greater (45 +/- 3 vs 36 +/- 3 pg/ml; p less than 0.05) in the hypertensive group. On univariate analysis, age (r = 0.52, n = 47, p less than 0.001) and creatinine clearance (r = -0.30, n = 47, p less than 0.05) were significantly related to plasma ANF concentrations, but arterial pressure was not (r = 0.14, n = 47), in an extended group of normal subjects. In contrast, plasma ANF values were related to arterial pressure in both an extended group of subjects with untreated essential hypertension (r = 0.54, n = 38, p less than 0.001) and in our total heterogeneous pool of hypertensive patients (r = 0.46, n = 79, p less than 0.001), but weak positive associations with age and inverse relationships with creatinine clearance were not statistically significant in either hypertensive group. Similar weak inverse relationships between plasma ANF values and renin-angiotensin-aldosterone system activity were found in both normal and hypertensive subjects.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Starting Page | 1174 |
| Ending Page | 1175 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/10/6/570.full.pdf |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/10/6/570.full.pdf?download=true |
| PubMed reference number | 2961687v1 |
| Volume Number | 10 |
| Issue Number | 6 |
| Journal | Hypertension |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aldosterone Angiotensins Atrial Natriuretic Factor Creatinine clearance measurement Essential Hypertension Genetic Heterogeneity Heart Atrium Mental association Natriuretic Hormones Patients Seventy Nine |
| Content Type | Text |
| Resource Type | Article |
