Effect of acute hypercapnia on alpha atrial natriuretic peptide, renin, angiotensin II, aldosterone, and vasopressin plasma levels in patients with COPD.

Content Provider	Semantic Scholar
Author	Chabot, François Mertes, Paul Michel Delorme, Nathalie Schrijen, Francine Saunier, C. G. Polu, Jean Marie
Copyright Year	1995
Abstract	Disturbances in hormonal systems involved in sodium and water homeostasis are common during respiratory insufficiency. To investigate the role of hypercapnia, we designed a study to examine the hormonal response to acute hypercapnia induced at constant cardiac filling pressures and without hypoxemia. Seven sedated patients with COPD receiving mechanical ventilation were studied during five successive periods. Hemodynamics, arterial blood gases, and plasma hormone levels (atrial natriuretic peptide, renin, angiotensin II, aldosterone, vasopressin) were measured three times during 60 min of acute hypercapnia (52 +/- 5 mm Hg) and at control periods, before (36 +/- 4 mm Hg) and after (42 +/- 3 mm Hg) acute hypercapnia. During acute hypercapnia, mean pulmonary arterial pressure and cardiac output were increased without variation of other measured cardiorespiratory data and hormonal levels when compared with control values. After acute hypercapnia, cardiorespiratory variables returned to control values without variations of hormonal levels. Our results show that moderate acute hypercapnia does not significantly influence the hormonal levels when cardiac filling pressures and sympathetic tone remain stable. We suggest that changes in those plasma hormones involved in salt and water homeostasis during acute hypercapnia are secondary to hemodynamic changes induced by acute respiratory failure and not to acute hypercapnia per se.
Starting Page	1
Ending Page	5
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://journal.publications.chestnet.org/pdfaccess.ashx?url=/data/journals/chest/21710/780.pdf
PubMed reference number	7874953v1
Volume Number	107
Issue Number	3
Journal	Chest
Language	English
Access Restriction	Open
Subject Keyword	Acute respiratory failure Aldosterone Angiotensin II Angiotensins Argipressin Atrial Natriuretic Factor Cardiac Output Chronic Obstructive Airway Disease Gases Heart Atrium Hemodynamics Hypoxia Mechanical ventilation Mercury Patients Respiration Respiratory Insufficiency Sodium alpha-Atrial Natriuretic Peptide water homeostasis
Content Type	Text
Resource Type	Article