NDLI: IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso.

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IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso.

Content Provider	Semantic Scholar
Author	Zeba, Boukaré Luca, Filomena De Dubus, Alain Delmarcelle, Michael Simpore, Jacques Nacoulma, Odile Germaine Rossolini, Gian Maria Frère, Jean-Marie Docquier, Jean-Denis
Copyright Year	2009
Abstract	The genus Chryseobacterium and other genera belonging to the family Flavobacteriaceae include organisms that can behave as human pathogens and are known to cause different kinds of infections. Several species of Flavobacteriaceae, including Chryseobacterium indologenes, are naturally resistant to beta-lactam antibiotics (including carbapenems), due to the production of a resident metallo-beta-lactamase. Although C. indologenes presently constitutes a limited clinical threat, the incidence of infections caused by this organism is increasing in some settings, where isolates that exhibit multidrug resistance phenotypes (including resistance to aminoglycosides and quinolones) have been detected. Here, we report the identification and characterization of a new IND-type variant from a C. indologenes isolate from Burkina Faso that is resistant to beta-lactams and aminoglycosides. The levels of sequence identity of the new variant to other IND-type metallo-beta-lactamases range between 72 and 90% (for IND-4 and IND-5, respectively). The purified enzyme exhibited N-terminal heterogeneity and a posttranslational modification consisting of the presence of a pyroglutamate residue at the N terminus. IND-6 shows a broad substrate profile, with overall higher turnover rates than IND-5 and higher activities than IND-2 and IND-5 against ceftazidime and cefepime.
File Format	PDF HTM / HTML
DOI	10.1128/AAC.01607-08
PubMed reference number	19651915
Journal	Medline
Volume Number	53
Issue Number	10
Alternate Webpage(s)	http://aac.asm.org/content/early/2009/08/03/AAC.01607-08.full.pdf
Alternate Webpage(s)	https://orbi.uliege.be/bitstream/2268/67233/1/1607-08.pdf
Alternate Webpage(s)	https://doi.org/10.1128/AAC.01607-08
Journal	Antimicrobial agents and chemotherapy
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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