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Pergolide interactions with nicotine and pilocarpine in rats on the radial-arm maze
| Content Provider | Semantic Scholar |
|---|---|
| Author | Levin, Edward D. |
| Copyright Year | 1995 |
| Abstract | Antagonists of nicotinic and muscarinic acetylcholinergic (ACh) receptors have significant interactions with dopaminergic (DA) ligands with regard to radial-arm maze choice accuracy. The current studies examined the interactions of agonists of nicotinic and muscarinic ACh receptors with the DA agonist pergolide. Pergolide given in a range from 0.03-1.0 mg/kg had no detectable effect on radial-arm maze choice accuracy when given alone. With this dose range there was a linear increase in response latency. Pergolide had significant interactive effects with the nicotinic and muscarinic agonists nicotine and pilocarpine. Given together with nicotine, pergolide produced a significantly elevated linear increase in accuracy relative to when it was given alone. With pilocarpine, pergolide had an inverted U-shaped effect improving choice accuracy at low to moderate doses of 0.03 and 0.1 mg/kg. These results support previous findings of DA-ACh interactions with regard to radial-arm maze choice accuracy. Combined DA-ACh treatment may be a useful treatment of cognitive dysfunction. |
| Starting Page | 837 |
| Ending Page | 840 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0091-3057(95)00165-S |
| PubMed reference number | 8587928 |
| Journal | Medline |
| Volume Number | 52 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/009130579500165S |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/009130579500165S?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0091-3057%2895%2900165-S |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
