Loading...
Please wait, while we are loading the content...
Similar Documents
Differential prolactin responses to Haloperidol and TRH in normal adult men
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hays, Sally E. Rubin, Robert T. |
| Copyright Year | 1981 |
| Abstract | Abstract (1) Prolactin (PRL) responses to low dose intravenous (i.v.) haloperidol differed among individuals, but PRL responses to 25 μg and 500 μg i.v. thyrotropin-releasing hormone (TRH) in the same subjects were similar. (2) Serum concentrations of haloperidol accounted for only 36% of the variability in PRL response. (3) It is concluded that the inter-individual variability in PRL response to haloperidol does not result from differences in pituitary PRL-secreting capacity, nor can it be attributed in a major way to differences in drug metabolism. It is proposed that the variable PRL responses to haloperidol reflect individual differences in dopamine receptor sensitivity to blockade by this drug. |
| Starting Page | 45 |
| Ending Page | 52 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0306-4530(81)90047-0 |
| PubMed reference number | 6787635 |
| Journal | Medline |
| Volume Number | 6 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0306453081900470 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0306453081900470?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0306-4530%2881%2990047-0 |
| Journal | Psychoneuroendocrinology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
