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Prolactin and TSH responses to TRH and to haloreridol in schizophrenic patients before and after treatment
| Content Provider | Semantic Scholar |
|---|---|
| Author | Markianos, Manolis Hatzimanolis, John Stefanis, Costas N. |
| Copyright Year | 1994 |
| Abstract | The prolactin (PRL) and the TSH responses to thyrotropin releasing hormone (TRH, 0.4 mg i.v.) and to haloperidol (5 mg i.m.) were studied in 11 male schizophrenic patients in a drug-free state and after treatment with haloperidol, 60 mg daily. The PRL responses observed after i.m. haloperidol in the drug-free state, on average 35.4 ng/ml, were abolished after treatment, indicating complete receptor blockade, while the PRL responses to TRH were preserved, although moderately reduced (from 19.4 to 14.8 ng/ml on average). The TSH responses to TRH were unaltered by the treatment (means 8.25 and 7.74 mIU/l). The results show that the TSH and partially the PRL releasing actions of TRH are not mediated via receptors that are effectively blocked by haloperidol. |
| Starting Page | 513 |
| Ending Page | 516 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0924-977X(94)90300-X |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0924977X9490300X |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0924977X9490300X?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 7894262 |
| Alternate Webpage(s) | https://doi.org/10.1016/0924-977X%2894%2990300-X |
| Journal | Medline |
| Volume Number | 4 |
| Journal | European Neuropsychopharmacology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
