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Antimicrobial Activity of Berberine-a Constituent of Mahonia aquifolium
| Content Provider | Semantic Scholar |
|---|---|
| Abstract | The antimicrobial activity of the protoberberine alkaloid, berberine, isolated from Mahonia aquifolium, was evaluated against 17 microorganisms including two Gram-negative bacteria Pseudomonas aeruginosa and Escherichia coli (both resistant and sensitive), two Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus, Zoogloea ramigera, six filamentous fungi Penicilium chrysogenum, Aspergillus niger, Aureobasidium pullulans (black and white strain), Trichoderma viride (original green strain and brown mutant), Fusarium nivale, Mycrosporum gypseum and two yeasts Candida albicans and Saccharomyces cerevisiae. The ICs0, minimum inhibitory concentration (MIC), minimum microbicidal concentration (MMC) and minimum microbistatic concentration (MMS) varied considerably depending on the microorganism tested, the sensitivity decreasing as follows: S. aureus > P. aeruginosa S (sensitive) > E. coli S > P. aeruginosa R (resistant)> E. coli R > B. subtilis > Z. ramigera > C. albicans > S.cerevisiae > ,4. pullulans B (black) > A. pullulans W (white) > T. viride Br (brown) > M. gypseum > A. niger > F. nivale > P. chrysogenum > T. viride G (green). Berberine is a well-known isoquinoline alkaloid isolated from Berberis, Mahonia, Coptis and other species that are commonly used in the herbal medicine in China and in other Asian countries for the treatment of patients with gastrointestinal disorders, and as an antibiotic (Iwasa et al. 1998a). Berberis aristata and B. asiatica are plants much used in Indian medical preparations, et al. 1999). As for the biological activities of berberine, it has been reported to have multiple pharmacological activities. It is an antibacterial agent against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria, fungi, protozoa, trypanosomes and plasmodia (Amin et aL 1969; Iwasa et al. 1998 a,b; Cowan 1999; Sarma et aL 1999; Merschjohann et al. 2001; Singh et aL 2001; Ameer Basha et al. 2002). The antimicrobial activity depended on the inoculum size of the tested organism and pH of the medium (Amin et al. 1969). The mechanism of action of the highly aromatic nearly planar quaternary structure of berberine is attributed to its ability to intercalate with DNA. The intercalation in combination with the for instance, as a hepatoprotector (Anis |
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| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
