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Effects of pro-opiomelanocortin fragments on release of catecholamines from adrenal chromaffin cells
| Content Provider | Semantic Scholar |
|---|---|
| Author | Boksa, Patricia Seidah, Nabil G. Chrétien, Michel Livett, Bruce G. |
| Copyright Year | 1982 |
| Abstract | The effects of pro-opiomelanocortin (POMC) peptide fragments on the basal and agonist-induced release of catecholamines (CAs) from monolayer cultures of purified bovine adrenal chromaffin cells were tested. None of the 5 peptides tested, i.e. beta-MSH, ACTH1-39, gamma-MSH1-13, gamma 3-MSH and N-terminal POMC fragment, had any effect on basal CA release. However, beta-MSH (10(-5) M), gamma-MSH1-13 (10(-6)-10(-5) M), gamma 3-MSH (10(-5) M) and N-terminal POMC fragment (10(-5) M) inhibited the nicotine-induced release of CAs from the chromaffin cells. The possible physiological significance of this inhibitory neuromodulation is discussed. |
| Starting Page | 199 |
| Ending Page | 204 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(82)90152-5 |
| PubMed reference number | 7070709 |
| Journal | Medline |
| Volume Number | 28 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0304394082901525 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0304394082901525?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2882%2990152-5 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
