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Re: Biologic characteristics of interval and screen-detected breast cancers.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Eisinger, François Juliain-Reynier, C. Sobol, Hagay |
| Copyright Year | 2000 |
| Abstract | In their recent work, Gilliland et al. (1) have shown that interval breast cancers, defined as cancers detected within 12 months after a negative mammography, are frequently high-grade, rapidly growing, and aggressive cancers. In particular, tumor proliferation rate and p53 overexpression are independent determinants of interval breast cancers, and these characteristics are seen more often among patients who are younger than 50 years of age. These features are reminiscent of what is observed for breast cancers associated with mutations in the BRCA1 gene (BRCA1-BCs) (2–4). The high proliferation rate of hereditary breast cancers and the resulting risk of interval cancer raise the important question of medical management of individuals at high genetic risk of breast cancer. In this respect, international published guidelines have recommended that mammographic screening should be carried out annually (5,6). However, based on the results of Gilliland et al. (1), it can be anticipated that even a period of 1 year, instead of the 2 years usually used in mass screening programs, might not fit with the bioclinical characteristics of BRCA1-BCs, which are close to those of interval breast cancers. Although decreasing the interval between mammograms may theoretically reduce the risk of interval cancers, this option has been poorly investigated. To explore the lowest acceptable interval between mammograms that would be acceptable to patients, we studied all women who attended a cancer genetic clinic during a 1-year period. Specifically, to these women, we presented an explanatory letter and a questionnaire to be filled in before their consultations. Patients were asked to indicate their preference among five mutually exclusive intervals: every 3 months, every 6 months, every year, every 2 years, and I don’t know. Among the 145 eligible women, 138 filled in the questionnaire (Table 1). Almost 40% (n 55) of the subjects had a history of cancer; the mean age of patients was 44.5 years (standard deviation 13.3 years). A majority of patients, 57.2% (n 79) indicated a preference for an annual examination; only 28.3% (n 39) indicated a preference for an interval of 6 months or less (Table 1). An important element that emerged from our study is the low proportion of patients who would accept a shorter interval between mammograms than that recommended in international guidelines on hereditary breast cancer risk |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jnci/92/18/10.1093_jnci_92.18.1533/1/1533.pdf?Expires=1492435009&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=Ltj5xIrC51pByQ7ttaWRY5EMtwHmEBKSd1o57uoL0wa7ulPtJ-4dbSHrGAyrtE5knrcGcW6fnurb2lh2NEN-gVPAhad-jpegK92xP9g-WyYJtXfKCmdu0nwP9zcw~qx7z14juYwbI31CXq4Ewpnqf8-vHlpUNfflktPWCqR7YOlfC6-UU44Zo-~QlaDdVv-9jjjSBZB5R3oaUb8KqdFjw4zv23KLQp3WnIBrn9a0WYtMc80iJ2IpJoAbaL~Z4rEbCw5Y85Tm~98LpRi~Tc39PPJWrqxgqv95g78wZgKdRUIC-HUOIFasNMbZGN5zTQW8efMGl6iGOtPjwga4polvEA__ |
| PubMed reference number | 10995812v1 |
| Volume Number | 92 |
| Issue Number | 18 |
| Journal | Journal of the National Cancer Institute |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Breast Cancer, Familial Consultation Fill Leukemia, Myeloid, Accelerated Phase Malignant Neoplasms Malignant neoplasm of breast Mammary Neoplasms Mammography Mass Screening Mutation Patients Scientific Publication Seventy Nine cancer genetics explanation |
| Content Type | Text |
| Resource Type | Article |
