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A basal epithelial phenotype is more frequent in interval breast cancers compared with screen detected tumors.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Collett, Karin Stefansson, Ingunn Marie Braaten, Audun Wang, Hege Eide, Geir Egil Thoresen, Steinar Osterbö Foulkes, William D. Akslen, Lars Andreas |
| Copyright Year | 2005 |
| Abstract | Interval breast cancer reduce the effectiveness of mammography screening programs. We studied 95 interval cancers, diagnosed during 1996 to 2001 as part of the population-based Norwegian Breast Cancer Screening Program. These cases were matched on size (+/-2.0 mm) to 95 screen-detected breast cancers, and the tumors were compared by immunohistochemical methods using tissue microarrays. Patients with interval cancers were more likely to be younger [odds ratio (OR), 4.7; P = 0.0001], to have dense breasts (OR, 3.4; P = 0.004), and to have estrogen receptor-negative tumors (OR, 2.6, P = 0.01), and p53 expression was more frequent (OR, 4.0; P = 0.001). Notably, interval cancers were more likely to have a basal epithelial phenotype, in that expression of cytokeratin 5/6 (OR, 2.3; P = 0.04) and P-cadherin (OR, 2.5; P = 0.04) was more frequent in interval cases than in size-matched, screen-detected tumors. In a logistic regression model, p53 expression, age, and breast density were independent predictors of interval cancers. Our data suggest that breast cancers with a basal epithelial phenotype are more likely than nonbasal breast cancers to present between regular mammograms. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://cebp.aacrjournals.org/content/cebp/14/5/1108.full.pdf |
| PubMed reference number | 15894660v1 |
| Volume Number | 14 |
| Issue Number | 5 |
| Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cadherins Cytokeratin Estrogens Malignant Neoplasms Malignant neoplasm of breast Mammary Neoplasms Odds Ratio Screening mammography estrogen receptor alpha, human |
| Content Type | Text |
| Resource Type | Article |
