NDLI: Pharmacological properties and functional role of a TRP-related ion channel in lobster olfactory receptor neurons.

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Pharmacological properties and functional role of a TRP-related ion channel in lobster olfactory receptor neurons.

Content Provider	Semantic Scholar
Copyright Year	2005
Abstract	Odors activate lobster olfactory receptor neurons (ORNs) through phosphoinositide signaling that appears to target a Na(+)-gated nonselective cation channel. The Na(+)-gated channel is a potential member of the growing family of transient receptor potential (TRP) channels. Here, we test the effect of potential antagonists on the channel in cell-free patches from cultured lobster ORNs. We show that the channel is antagonized by H+ and the TRP channel blockers 2-aminoethoxydiphenyl borate, SKF96365, ruthenium red, Al3+, Gd3+, and La3+. We then use this enhanced antagonist profile together with the agonists Na+ and Ca2+ to implicate the channel in signal amplification in the cells.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://jn.physiology.org/content/jn/93/3/1372.full.pdf
Alternate Webpage(s)	http://jn.physiology.org/content/jn/early/2004/11/03/jn.00990.2004.full.pdf
PubMed reference number	15525800v1
Volume Number	93
Issue Number	3
Journal	Journal of neurophysiology
Language	English
Access Restriction	Open
Subject Keyword	2-aminoethoxydiphenyl borate Activation action Borates Calcium ion Cations Ion Channel Iontophoresis Olfactory Receptor Cells Pharmacology Phosphatidylinositols Receptors, Odorant Ruthenium Red SK&F 96365 Sodium Ulnar hypoplasia lobster claw deformity of feet aluminum cation
Content Type	Text
Resource Type	Article

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