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doi:10.1093/chemse/bji008 Cyclic Nucleotide Signaling Mediates an Odorant-suppressible Chloride Conductance in Lobster Olfactory Receptor Neurons
| Content Provider | CiteSeerX |
|---|---|
| Author | Doolin, Richard E. Ache, Barry W. |
| Abstract | We have previously shown that lobster olfactory receptor neurons (ORNs) express an odorant-suppressible Cl ÿ conductance that modulates the output of the cells. Here, we develop a more complete pharmacological profile of this conductance, showing it is blockable by the Cl ÿ channel blockers DIDS, 9-AC and flufenamic acid, but not by niflumic acid. We then show that a conductance with this pharmacological profile is mediated by cyclic nucleotide signaling. These findings further our understanding of the cellular mechanisms through which odorants can modulate the output of lobster ORNs. Key words: Cl ÿ conductance, cyclic nucleotide signalling, lobster, olfaction |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Niflumic Acid Lobster Olfactory Receptor Neuron Olfactory Receptor Neuron Pharmacological Profile Flufenamic Acid Complete Pharmacological Profile Lobster Orns Cl Conductance Odorant-suppressible Chloride Conductance Cellular Mechanism Cl Channel Blocker Dids Odorant-suppressible Cl Conductance |
| Content Type | Text |