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ミルクの機能性について : 骨の健康に寄与する牛乳由来の成分"mbp"
| Content Provider | Semantic Scholar |
|---|---|
| Author | 雪印乳業技術研究所・雪印乳業商品開発本部 雪印乳業商品開発本部 |
| Copyright Year | 2001 |
| Abstract | MBP antibodies are detected in various neuroimmune disorders including multiple sclerosis. Consequently, antibodies to MBP are accepted markers of inflammation in various neuroimmune disorders. In possible cases of multiple sclerosis the measurement of antibodies against MBP may predict early conversion to clinically definite multiple sclerosis; in a study by Berger et al patients who were seropositive for both antibodies, anti-MBP and anti-myelin oligodendrocyte glycoprotein, had clinically definite multiple sclerosis within a mean of 7.5 months.2 To increase the sensitivity and specificity of MS diagnosis, a combination of antibodies, lymphocyte activation or cytokine production assessments along with an MRI, should be utilized.2 5 Autism Spectrum Disorder (ASD) presents with multiple biomolecular manifestations including neurological dysfunction. Compared to control subjects, ASD patients possess significantly higher levels of anti-brain antibodies, such as MBP, serotonin receptor, and brain endothelial cells or blood-brain barrier.1 Due to cross-reactivity to Streptococcal protein, MBP antibody is also found in PANDAS (pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection), its adult version ANDAS and Obsessive Compulsive Disorder (OCD).6 Indeed, the similarities of peptide sequences between Streptococcal proteins and MBP result in cross-reactivity. This autoimmune response triggers inflammation via myelin basic protein-specific T-cells, thus compromising the blood-brain barrier.3 5 A point of interest is that the administration of myelin basic protein artificially increases blood-brain barrier permeability and is under research as a possible treatment for rabies virus, which enters the brain to replicate itself.4 Multiple sclerosis2 5 Autism1 PANDAS / ANDAS / OCD6 Lupus Toxin exposure |
| Starting Page | 209 |
| Ending Page | 214 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Volume Number | 12 |
| Alternate Webpage(s) | http://thelivingproofinstitute.com/wp-content/uploads/2014/01/a5MBP.pdf |
| Alternate Webpage(s) | http://maypro.com/sites/default/files/studies/MBP%20White%20Paper.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
