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Modified donor lymphocyte infusion-associated acute graft-versus-host disease after haploidentical T-cell-replete hematopoietic stem cell transplantation: incidence and risk factors.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yan, Chen-Hua Liu, Dai-Hong Xu, Lan-Ping Liu, Kai-Yan Zhao, Ting Wang, Yu Chen, Huan Chen, Yongmei Huang, Xiao-Jun |
| Copyright Year | 2012 |
| Abstract | We performed a study to investigate the profile of donor lymphocyte infusion (DLI)-associated acute graft-versus-host disease (GVHD) in haploidentical T-cell-replete hematopoietic stem cell transplantation (HSCT). A total of 124 patients receiving modified DLI after haploidentical T-cell-replete HSCT were enrolled. The cumulative incidence of DLI-associated acute GVHD was 53.2% for grades II-IV and 28.4% for grades III-IV. The duration of GVHD prophylaxis after DLI was the only risk factor for DLI-associated grades III-IV acute GVHD (p<0.05). The cumulative incidence of grades III-IV acute GVHD in patients with prophylaxis more than six, four to six, two to four, and <2 wk were 9.3%, 14.4%, 31.6%, and 49.5%, respectively (p=0.018). Furthermore, DLI-associated grades III-IV acute GVHD was the only risk factor for overall survival (p=0.038, OR=2.869) and transplant-related mortality (p=0.018, OR=3.296) but not a risk factor for relapse after DLI (p=0.840). This study confirms for the first time that the duration of GVHD prophylaxis after DLI is the only risk factor for the development of grades III-IV acute GVHD. Donor lymphocyte infusion with prophylaxis more than six wk was associated with a lower incidence of grades III-IV acute GVHD. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 22432715 |
| Journal | Medline |
| Volume Number | 26 |
| Issue Number | 6 |
| Alternate Webpage(s) | http://www.pubstemcell.com/monthly/uploads/007030700057.pdf |
| Alternate Webpage(s) | https://doi.org/10.1111/j.1399-0012.2012.01618.x |
| Journal | Clinical transplantation |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
