Loading...
Please wait, while we are loading the content...
Similar Documents
Combination of anti‐ CD 4 antibody treatment and donor lymphocyte infusion ameliorates graft‐ versus ‐host disease while preserving graft‐ versus ‐tumor effects in murine allogeneic hematopoietic stem cell transplantation
| Content Provider | Scilit |
|---|---|
| Author | Ueha, Satoshi Yokochi, Shoji Ishiwata, Yoshiro Kosugi‐Kanaya, Mizuha Shono, Yusuke Shibayama, Shiro Ito, Satoru Matsushima, Kouji |
| Copyright Year | 2017 |
| Description | Journal: Cancer Science Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is not only a well‐established immunotherapy for hematologic malignancies, but is potentially useful for treating solid tumors refractory to available therapies. However, application of allo‐HSCT to solid tumors is limited, despite the beneficial antitumor effects, by the risk of graft‐versus‐host disease (GVHD). CD4+ T cells have been implicated in several aspects of GVHD, and suppress antitumor CD8+ T‐cell responses. In the present study, we investigated clinically applicable allo‐HSCT protocols designed to maximize antitumor effects while reducing the risk of GVHD. We used a mouse model of allo‐HSCT with s.c. tumors. We found that myeloablative conditioning was associated with better inhibition of tumor growth but with severe acute GVHD. Early treatment with anti‐CD4 mAb substantially ameliorated GVHD while preserving antitumor effects, leading to improved survival in myeloablative allo‐HSCT. Late treatment with anti‐CD4 mAb also ameliorated GVHD to some extent. Donor lymphocyte infusion in GVHD mice treated with anti‐CD4 mAb further suppressed tumor growth without exacerbating GVHD. Collectively, our results suggest that myeloablative allo‐HSCT followed by anti‐CD4 mAb treatment and donor lymphocyte infusion could be a potent and safe immunotherapy for patients with cancers refractory to available therapies. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623734/pdf |
| Ending Page | 1973 |
| Page Count | 7 |
| Starting Page | 1967 |
| e-ISSN | 13497006 |
| DOI | 10.1111/cas.13346 |
| Journal | Cancer Science |
| Issue Number | 10 |
| Volume Number | 108 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2017-08-29 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cancer Science Research and Experimental Medicine Allogeneic Hematopoietic Stem Cell Transplantation Donor Lymphocyte Infusion Graft‐versus‐host Disease Graft‐versus‐tumor |
| Content Type | Text |
| Resource Type | Article |
