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Il ruolo della Venlafaxina nella terapia della depressione unipolare con manifestazioni di dolore somatico Role of Venlafaxine in the treatment of unipolar depression associated with painful somatic symptoms
| Content Provider | Semantic Scholar |
|---|---|
| Author | Siracusano, Alberto Troisi, Alfonso |
| Copyright Year | 2005 |
| Abstract | Summary Objective Depression is increasingly seen as a triad of psychological, somatic and physical symptoms that all need to be treated to achieve maximal remission. In primary care, physical symptoms, such as pain, are often the main presenting symptoms. A major depressive disorder is not infrequently encountered in daily clinical practice, often presenting with somatic complaints that include various type of pain, and these may be so prominent as to direct the treatment to the evaluation of the somatic complaint to the exclusion of the underlying psychopathology. It has been suggested that the class of serotonin and norepinephrine reuptake inhibitors (SNRI), which includes Venlafaxine, may be useful in relieving not only psychological symptoms but also chronic pain associated with unipolar depression. The present study aimed at testing this hypothesis in a large group of outpatients with depression. Methods A total of 475 patients completed a 16-week trial with SNRI (Venlafaxine), SSRIs or TCAs (Table I). Baseline and outcome assessment included the Hamilton Depression Rating Scale (HAM-D), the Improvement scale of the Clinical Global Impression (CGI-I), and the Visual Analogue Scale (VAS) for the evaluation of painful somatic symptoms. Patients with past or current organic mental disorders, manic or hypomanic symptoms, psychotic symptoms were excluded from the study. Enrolled patients had a mean age of 46 years, a mean illness duration of 3 years, and a mean previous period of antidepressant treatment of 2 years. Statistical analysis included Pearson coefficient of correlation for calculating bivariate correlations between continuous variables, analysis of variance (ANOVA) or covariance (ANCOVA) for comparing scores of groups of patients treated with different classes of antidepressant drugs, and regression logistic analysis for identifying significant predictors of response and remission. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jpsychopathol.it/wp-content/uploads/2015/08/siracusano1.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
