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Synthesis and anticonvulsant activity of new 3 '-aryl-7-bromo-spiro [ [ 1 ] benzothiophene-3 , 2 '-[ 1 , 3 ] thiazolidine ]-2 , 4 '-dione derivatives ASHRAF
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zaher, Fadi M. Khalil, Ahmed Mohamed Aly Ahmed, Eman Mohamed |
| Copyright Year | 2011 |
| Abstract | Two series of spiro[ [1]benzothiophene-3,2'-[1,3]thiazolidine]-2,4'-diones 5a-e and 6a-e were synthesized, characterized and evaluated for anticonvulsant activity. Reaction of [1]benzothiophene-2,3-dione (3) with certain arylamines afforded the corresponding Schiff bases 4a-e. Cyclization of 4a-e with thioglycolic or thiolactic acids brought about the target spiro compounds 5a-e and 6a-e respectively. Spectral data, IR and 1H-NMR proved that the structure of the spiro compounds 5a-e and 6a-e might be in a mixture of two forms or derivatives of [1,3]thiazolidinone and / or hydroxy[1,3]thiazole. The final compounds were tested for their anticonvulsant activity. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.orientjchem.org/download/29556/ |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
