Loading...
Please wait, while we are loading the content...
Similar Documents
Synthesis and 5-HT1A/5-HT2A receptor activity of new N-[3-(4-phenylpiperazin-1-yl)-propyl] derivatives of 3-spiro-cyclohexanepyrrolidine-2,5-dione and 3-spiro-beta-tetralonepyrrolidine-2,5-dione.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Obniska, Jolanta Pawłowski, Maciej. Kołaczkowski, Marcin Czopek, Anna Duszyńska, Beata Kłodzińska, Aleksandra Tatarczyńska, Ewa Chojnacka-Wójcik, Ewa |
| Copyright Year | 2003 |
| Abstract | Novel N-[3-(4-phenylpiperazin-1-yl)-propyl] derivatives of 3-spiro-cyclo-hexanepyrrolidine-2,5-dione (5-7) and 3-spiro-beta-tetralonepyrrolidine-2,5-dione (8-10) were synthesized and their 5-HT1A and 5-HT2A receptor affinities were determined. All tested compounds exhibited moderate to low 5-HT1A receptor affinity, whereas compounds 5-7 demonstrated high 5-HT2A receptor affinity (Ki = 27, 46 and 15 nM, respectively) and features of 5-HT2A receptor antagonists. Introduction of a beta-tetralone fragment in the 3-position of pyrrolidine-2,5-dione ring (8-10) did not affect 5-HT1A but decreased 5-HT2A receptor affinity. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 14581713 |
| Journal | Medline |
| Volume Number | 55 |
| Issue Number | 4 |
| Alternate Webpage(s) | http://if-pan.krakow.pl/pjp/pdf/2003/4_553_ab.pdf |
| Alternate Webpage(s) | http://rabbit.if-pan.krakow.pl/pjp/pdf/2003/4_553_ab.pdf |
| Alternate Webpage(s) | http://www.if-pan.krakow.pl/pjp/pdf/2003/4_553_ab.pdf |
| Journal | Polish journal of pharmacology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |