NDLI: Our research on proton pumping ATPases over three decades: their biochemistry, molecular biology and cell biology

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Our research on proton pumping ATPases over three decades: their biochemistry, molecular biology and cell biology

Content Provider	Semantic Scholar
Author	Futai, Masamitsu
Copyright Year	2006
Abstract	ATP is synthesized by F-type proton-translocating ATPases (F-ATPases) coupled with an electrochemical proton gradient established by an electron transfer chain. This mechanism is ubiquitously found in mitochondria, chloroplasts and bacteria. Vacuolar-type ATPases (V-ATPases) are found in endomembrane organelles, including lysosomes, endosomes, synaptic vesicles, etc., of animal and plant cells. These two physiologically different proton pumps exhibit similarities in subunit assembly, catalysis and the coupling mechanism from chemistry to proton transport through subunit rotation. We mostly discuss our own studies on the two proton pumps over the last three decades, including ones on purification, kinetic analysis, rotational catalysis and the diverse roles of acidic luminal organelles. The diversity of organellar proton pumps and their stochastic fluctuation are the important concepts derived recently from our studies.
Starting Page	416
Ending Page	438
Page Count	23
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/d2/6d/82_416.PMC4338836.pdf
PubMed reference number	25792771v1
Volume Number	82
Journal	Proceedings of the Japan Academy. Series B, Physical and biological sciences
Language	English
Access Restriction	Open
Subject Keyword	Acids Adenosine Triphosphatases Bacteria Biochemistry Catalysis Chloroplasts Electron Transport Endosomes Kinetics Lysosomes Mitochondria Molecular Biology Organelles Phenobarbital Plant Cells Proton Pump Proton-Phosphate Symporters Proton-Translocating ATPases Protons Synaptic Vesicles Vesicle (morphologic abnormality) proton transport pump (device)
Content Type	Text
Resource Type	Article

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