NDLI: Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica serovar Typhimurium vaccine strains.

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Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica serovar Typhimurium vaccine strains.

Content Provider	Semantic Scholar
Author	Massis, Liliana Moura Sbrogio-Almeida, Maria Elisabete Lauand, Camila Ferreira, Luís Carlos De Souza
Copyright Year	2008
Abstract	In the present study we investigated the flagellin-specific serum (IgG) and fecal (IgA) antibody responses elicited in BALB/c mice immunized with isogenic mutant derivatives of the attenuated Salmonella enterica serovar Typhimurium (S. Typhimurium) SL3261 strain expressing phase 1 (FliCi), phase 2 (FljB), or no endogenous flagellin. The data reported here indicate that mice orally immunized with recombinant S. Typhimurium strains do not mount significant systemic or secreted antibody responses to FliCi, FljB or heterologous B-cell epitopes genetically fused to FliCi. These findings are particularly relevant for those interested in the use of flagellins as molecular carriers of heterologous antigens vectored by attenuated S. Typhimurium strains.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.bioline.org.br/pdf?oc08110
Alternate Webpage(s)	http://www.k-state.edu/bmb/labs/pek/EPrints/MassisEtal08.pdf
PubMed reference number	18949334v1
Volume Number	103
Issue Number	6
Journal	Memorias do Instituto Oswaldo Cruz
Language	English
Access Restriction	Open
Subject Keyword	Antigens, Heterophile B-Lymphocytes Cell secretion Epitopes Flagellin Immunoglobulin A Oral cavity Recombinants Salmonella XXX Cult Salmonella enterica subsp. enterica serovar enteritidis Salmonella infections Serotype
Content Type	Text
Resource Type	Article

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