Loading...
Please wait, while we are loading the content...
Similar Documents
Studies on the mechanism of oxygen-induced hypoventilation. An experimental approach.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Barnett, Thomas B. |
| Copyright Year | 1962 |
| Abstract | Increase in arterial blood carbon dioxide tension and hydrogen ion concentration is associated with a prompt increase in alveolar ventilation. Hypoxia of moderate degree has no appreciable effect on ventilation under normal circumstances nor does the administration of oxygen to the normal subject result in a decrease in ventilation. This may not be true, however, in certain disease states. Beddard and Pembrey (2), in 1908, noted a decrease in ventilation when patients with chronic pulmonary disease were allowed to breathe oxygen. In 1931, Barach and Richards (3) made similar observations in a patient with pulmonary insufficiency. The decreased ventilation in their case was accompanied by a marked rise in arterial Pco2. It was not until much later that it became generally recognized that the hypoventilation associated with the administration of oxygen to patients with pulmonary emphysema may result in serious respiratory acidosis, coma, and even death (4, 5). The mechanisms responsible for the hypoventilation accompanying oxygen administration remain obscure. Since patients with emphysema are known to have a diminished ventilatory response to increased concentration of carbon dioxide in the inspired air (6, 7), the most attractive hypothesis regarding the mechanism of oxygen-induced hypoventilation has been that hypoxia takes on a more important role in the over-all ventilatory drive when the response to the C02-pH stimulus is no longer normal. Under these circumstances, the administration of oxygen eliminates the hypoxic stimulus, thus leading to hypoventilation. The relative importance of adaptive mechanisms (acclimatization) and mechanical factors |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://dm5migu4zj3pb.cloudfront.net/manuscripts/104000/104487/cache/104487.1-20140626150500-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf |
| Alternate Webpage(s) | http://dm5migu4zj3pb.cloudfront.net/manuscripts/104000/104487/JCI62104487.pdf |
| PubMed reference number | 13865120v1 |
| Volume Number | 41 |
| Journal | The Journal of clinical investigation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acclimatization Acidosis Acidosis, Respiratory Arterial Occlusive Diseases Cessation of life Chronic Obstructive Airway Disease Comatose Hydrogen-Ion Concentration Hypoventilation Hypoxia Inspiration function Ions Lung diseases Oxygen Therapy Care Patients Protons Pulmonary Emphysema Pulmonary Valve Insufficiency Respiration carbon dioxide tension |
| Content Type | Text |
| Resource Type | Article |
