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Effect of long-term oxygen therapy on survival in patients with chronic obstructive pulmonary disease with moderate hypoxaemia.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Górecka, Dorota Gorzelak, K. Śliwiński, Pawel Tobiasz, M. Zielinski, Jill |
| Copyright Year | 1997 |
| Abstract | BACKGROUND To date only two controlled studies have been published on the effects of domiciliary oxygen treatment on survival in patients with chronic obstructive pulmonary disease (COPD) with advanced respiratory failure. The survival in such patients despite oxygen treatment remains poor. The prescription of long term oxygen therapy (LTOT) in less severe disease remains controversial. The aim of this study was to evaluate the rationale for prescribing oxygen to patients with COPD with moderate hypoxaemia. METHODS One hundred and thirty five patients with COPD, with PaO2 7.4-8.7 kPa (56-65 mmHg) and advanced airflow limitation (mean (SD) forced expiratory volume in one second (FEV1) 0.83 (0.28) 1), were randomly allocated to a control (n = 67) and LTOT (n = 68) group. The patients were followed every three months for at least three years or until death. RESULTS The cumulative survival rate was 88% at one year, 77% at two years, and 66% at three years. No significant differences were found in survival rates between patients treated with LTOT and controls, nor did longer oxygen use (over 15 hours per day) improve survival. Younger age, better spirometric values, and higher body mass index predicted better survival. CONCLUSIONS Domiciliary oxygen treatment does not prolong survival in patients with COPD with moderate hypoxaemia. Airway limitation seems to determine survival in this group of patients. |
| Starting Page | 15 |
| Ending Page | 26 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://thorax.bmj.com/content/thoraxjnl/52/8/674.full.pdf |
| Alternate Webpage(s) | http://taiss.com/gepoc/gecarp/gepubli/publdoc/078-066-goreckad-effect-long-term-oxygen-therapy-on-survival.pdf |
| PubMed reference number | 9337824v1 |
| Volume Number | 52 |
| Issue Number | 8 |
| Journal | Thorax |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Body mass index Burnett Schwartz Berberian syndrome Cessation of life Chronic Obstructive Airway Disease Expiration, function Hypoxia Lung Diseases, Obstructive Lung diseases Oxygen Therapy Care Oxygen measurement, partial pressure, arterial Patients Respiratory Insufficiency Scientific Publication per hour torr |
| Content Type | Text |
| Resource Type | Article |
