Loading...
Please wait, while we are loading the content...
Similar Documents
Impacto da hipertensão arterial sobre fluxo de sangue cerebral em pacientes com a doença de Alzheimer
| Content Provider | Semantic Scholar |
|---|---|
| Author | Attier-Zmudka, Jadwiga Bouzerar, Roger Gondry, Catherine Couvillers, Frédérique Chaarani, Bader Balédent, Olivier |
| Copyright Year | 2017 |
| Abstract | Alzheimer disease (AD). OBJECTIVE: The objective was to evaluate the potential impact of hypertension on cerebral vascular flows in a sample of Alzheimer's patients. METHODS: 19 patients with AD, including 10 with hypertension (aHT+) and 9 without hypertension (aHT-) were recruited. They underwent clinical evaluation and phase-contrast MRI protocol for flow assessment. Cerebral arterial flow distributions were evaluated using kurtosis and skewness indices at the intracranial and extracranial levels. RESULTS: No significant differences were found in the mean arterial flow, pulse flow and kurtosis between the levels in the AD aHT+ population. There was a significant difference in skewness between extraand intracranial levels (p = 0.01). No significant differences were found in the mean arterial flow between the levels in the AD aHTpopulation. A significant difference was observed in the pulse flow (p = 0.03), kurtosis (p = 0.02) and skewness (p = 0.008) between the levels. At the extracranial level we did not find any significant differences in the mean arterial flow, pulse flow or skewness between aHT+ and aHT-. There was a significant difference in kurtosis at the extracranial level between the aHT+ and aHT(p = 0.03). At the intracranial level, there were no significant differences in all parameters. CONCLUSION: Results showed a difference between cerebral vasculature in AD for aHT+ and aHTgroups. This is probably related to the loss of arterial compliance induced by the degradation of the vascular system. |
| Starting Page | 107 |
| Ending Page | 115 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.5327/Z2447-211520171700032 |
| Volume Number | 11 |
| Alternate Webpage(s) | http://ggaging.com/export-pdf/432/v11n3a02.pdf |
| Alternate Webpage(s) | http://ggaging.com/export-pdf/432/en_v11n3a02.pdf |
| Alternate Webpage(s) | https://doi.org/10.5327/Z2447-211520171700032 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
